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Human APE1/APE Recombinant Protein (RPES2965)

SKU:
RPES2965
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Epigenetics & Nuclear Signaling
$510
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Description

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Human APE1/APE Recombinant Protein

Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the damaged bases in your DNA are removed by the DNA glycosylase; APE1 cuts the AP site to allow resynthesis and ligation to finish the repair. APE1 stimulates the DNA binding activity of many transcription factors; which participate in cancer promotion and progression. APE1 controls the redox status of several transcription factors, such as c-Jun; c-Fos; NF-kB; and p53. APEN is also involved in calcium-dependent down-regulation of PTH expression. Human APE1/APE Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.