ApoM (apolipoprotein M) is an apolipoprotein and member of the lipocalin protein family. The lipocalins share limited regions of sequence homology and a common tertiary structure architecture. They have an eight-stranded; antiparallel; symmetrical _-barrel fold; which is in essence a beta sheet which has been rolled into a cylindrical shape. Inside this barrel is located a ligand binding site. They transport small hydrophobic molecules such as steroids; bilins; retinoids; and lipids. Lipocalins have been associated with many biological processes; among them immune response; pheromone transport; biological prostaglandin synthesis; retinoid binding; and cancer cell interactions. Lipocalins are comparatively small in size; and are thus less complicated to study as opposed to large; bulky proteins. They can also bind to various ligands for different biological purposes. ApoM is associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. ApoM is involved in lipid transport and can bind sphingosine-1-phosphate; myristic acid; palmitic acid and stearic acid; retinol; all-trans-retinoic acid and 9-cis-retinoic acid.
Product Name:
Human APOM Recombinant Protein (RPES4977)
Product Code:
RPES4977
Size:
20µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
Apolipoprotein M, Apo-M, ApoM, Protein G3a, APOM, G3A, NG20
Accession:
O95445
Sequence:
Met 1-Asn 188
Fusion tag:
C-Fc
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human APOM (O95445) (Met 1-Asn 188) was fused with the Fc region of human IgG1 at the C-terminus.
Purity:
> 85 % as determined by reducing SDS-PAGE.
Mol Mass:
45.6 kDa
AP Mol Mass:
50 kDa
Formulation:
Lyophilized from sterile PBS; pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
