The protein encoded by this gene is an evolutionarily conserved 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain. It has been reported that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines. There are many relationships between non-Hodgkin's lymphoma, diffuse large cell lymphoma and BCL6’s translocations. BCL6 can repress transcription from promoters linked to its DNA target sequence and this activity is dependent upon specific DNA-binding and the presence of an intact N-terminal half of the protein.
Product Name:
BCL6/B-cell CLL lymphoma 6 Recombinant Protein (RPES0334)
Product Code:
RPES0334
Size:
100 µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
BCL5,BCL6A,LAZ3,ZBTB27,ZNF51
Accession:
P41182
Sequence:
Met 1-Met 150
Fusion tag:
N-His & Trx
Endotoxin:
Please contact us for more information.
Protein Construction:
A DNA sequence encoding the human BCL6 (P41182) N-terminal fragment (Met 1-Met 150) was fused with a Trx and a polyhistidine tag at the N-terminus.
Purity:
> 92 % as determined by reducing SDS-PAGE.
Mol Mass:
34.2 kDa
AP Mol Mass:
33 kDa
Formulation:
Lyophilized from sterile 20mM Tris, 10% glycerol, pH 8.0
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
