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BCL6/B-cell CLL lymphoma 6 Recombinant Protein (RPES0334)

SKU:
RPES0334
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Immunology
$648
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Description

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BCL6/B-cell CLL lymphoma 6 Recombinant Protein

The protein encoded by this gene is an evolutionarily conserved 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain. It has been reported that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines. There are many relationships between non-Hodgkin's lymphoma, diffuse large cell lymphoma and BCL6’s translocations. BCL6 can repress transcription from promoters linked to its DNA target sequence and this activity is dependent upon specific DNA-binding and the presence of an intact N-terminal half of the protein.