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Human CD46 Recombinant Protein (RPES5245)

SKU:
RPES5245
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Immunology
€236
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Description

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Human CD46 Recombinant Protein

CD46/MCP has cofactor activity for the inactivation of complement components C3b and C4b by serum factor I, which protects autologous cells against complement-mediated injury. The protein CD46/MCP may play a role in the fusion of the spermatozoa with the ovum during fertilization. CD46/MCP also acts as a costimulatory molecule for T-cells, prompting the transformation of CD4+ cells into T-regulatory 1 cells. CD46/MCP gene mutations have been linked with hemolytic uremic syndrome. The pathways regulated by CD46/MCP include the Immune response Lectin-induced complement system and NF-kappaB Signaling. Human CD46 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.

Product Name:Human CD46 Recombinant Protein (RPES5245)
Product Code:RPES5245
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Membrane Cofactor Protein, TLX, Trophoblast Leukocyte Common Antigen, CD46, MCP, MIC10,AHUS2,TLX,TRA2.10
Accession:P15529
Sequence:Cys35-Asp328
Fusion tag:C-6His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human CD46 is produced by our Mammalian expression system and the target gene encoding Cys35-Asp328 is expressed with a 6His tag at the C-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:33.8 kDa
AP Mol Mass:55 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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