Human IDH1 Recombinant Protein (RPES2687)
- SKU:
- RPES2687
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Metabolism
Frequently bought together:
Description
system_update_altDatasheet
Human IDH1 Recombinant Protein
Isocitrate Dehydrogenase [NADP] Cytoplasmic (IDH1) belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 exists as a homodimer; binding one magnesium or manganese ion per subunit. Mutations of IDH1 have been shown to cause metaphyseal chondromatosis with aciduria and are involved in the development of glioma IDH plays a role in the regeneration of NADPH for intraperoxisomal reductions; such as the conversion of 2; 4-dienoyl-CoAs to 3-enoyl-CoAs; as well as in peroxisomal reactions that consume 2-oxoglutarate; namely the ?-hydroxylation of phytanic acid.
| Product Name: | Human IDH1 Recombinant Protein (RPES2687) |
| Product Code: | RPES2687 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | E.coli |
| Synonyms: | Isocitrate Dehydrogenase [NADP] Cytoplasmic, IDH, Cytosolic NADP-Isocitrate Dehydrogenase, IDP, NADP(+)-Specific ICDH, Oxalosuccinate Decarboxylase, IDH1, PICD |
| Accession: | O75874 |
| Sequence: | Met 1-Leu414 |
| Fusion tag: | C-8His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Isocitrate Dehydrogenase [NADP] Cytoplasmic is produced by our E.coli expression system and the target gene encoding Met1-Leu414 is expressed with a 8His tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 48.1 kDa |
| AP Mol Mass: | 39-54 kDa |
| Formulation: | Supplied as a 0.2 µm filtered solution of 50mM Tris; 200mM NaCl; 10% glycerol; pH8.0. |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
