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Human CD47/IAP Recombinant Protein (RPES1160)

SKU:
RPES1160
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Cell Biology
€196
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Description

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Human CD47/IAP Recombinant Protein

CD47(Integrin-Associated Protein;IAP) is a 40 - 60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. The ubiquitously expressed CD47 binds to SIRP family members on macrophages; neutrophils; and T cells. CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The protein is also a receptor for the C-terminal cell-binding domain of thrombospondin; and it may play a role in membrane transport and signal transduction. This protein has broad tissue distribution; and is reduced in expression on Rh erythrocytes.

Product Name:Human CD47/IAP Recombinant Protein (RPES1160)
Product Code:RPES1160
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Leukocyte Surface Antigen CD47, Antigenic Surface Determinant Protein OA3, Integrin-Associated Protein, IAP, Protein MER6, CD47, MER6
Accession:Q08722
Sequence:Gln19-Pro139
Fusion tag:C-His
Activity:Immobilized Human SIRPA-Fc(Cat: PKSH033061) at 10µg/ml(100 ?l/well) can bind Human CD47-His. The ED50 of Human CD47-His is 4.18 ng/ml .
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human CD47 is produced by our Mammalian expression system and the target gene encoding Gln19-Pro139 is expressed with a 6His tag at the C-terminus.
Purity:> 95% as determined by reducing SDS-PAGE.
Mol Mass:14.76 kDa
AP Mol Mass:34 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 10mM Tris-Citrate; 150mM NaCl; pH 8.0.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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