CDK2AP2; also known as DOC1R; is short for cyclin-dependent kinase 2-associated protein 2. The gene CDK2AP2 encodes this protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene. It belongs to the CDK2AP family. CDK2AP1 (cyclin-dependent kinase 2-associated protein 1); corresponding to the gene doc-1 (deleted in oral cancer 1); is a tumor suppressor protein. The doc-1 gene is absent or down-regulated in hamster oral cancer cells and in many other cancer cell types. The ubiquitously expressed CDK2AP1 protein is the only known specific inhibitor of CDK2; making it an important component of cell cycle regulation during G(1)-to-S phase transition.
Product Name:
Human CDK2AP2 Recombinant Protein (RPES0257)
Product Code:
RPES0257
Size:
10µg
Species:
Human
Expressed Host:
Human Cells
Synonyms:
Cyclin-dependent kinase 2-associated protein 2,CDK2-associated protein 2,DOC-1-related protein,DOC-1R,CDK2AP2,DOC1R,p14
Accession:
O75956
Sequence:
Met 1-Thr126
Fusion tag:
C-6His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Cyclin-Dependent Kinase 2-Associated Protein 2 is produced by our Mammalian expression system and the target gene encoding Met1-Thr126 is expressed with a 6His tag at the C-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
14.1 kDa
AP Mol Mass:
26 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of PBS; pH7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
