DLG4/PSD95 is a member of the MAGUK family. After heteromultimerizing with another MAGUK protein, DLG2, DLG4 is recruited into NMDA receptor and potassium channel clusters. The MAGUK proteins may act as a multimeric scaffold for the clustering of receptors, ion channels, and associated signalling molecules at postsynaptic sites. Encephalopathy, progressive, early-onset, with episodic rhabdomyolysis and intellectual developmental disorder, autosomal dominant 62 are two diseases linked to DLG4. Post NMDA receptor activation events and RET signalling are 2 related pathways of DLG4. Human DLG4 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human DLG4 Recombinant Protein (RPES2419)
Product Code:
RPES2419
Size:
10µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
Disks large homolog 4, Postsynaptic density protein 95, PSD-95, Synapse-associated protein 90, SAP-90, SAP90, PSD95, DLG4
Accession:
P78352
Sequence:
Met 1-Leu724
Fusion tag:
N-6His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Postsynaptic Density Protein 95 is produced by our E.coli expression system and the target gene encoding Met1-Leu724 is expressed with a 6His tag at the N-terminus.
Purity:
> 90 % as determined by reducing SDS-PAGE.
Mol Mass:
81.9 kDa
AP Mol Mass:
110 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
