Ferritin heavy polypeptide 1(FTH1); is a ubiquitous intracellular protein which stores iron in a soluble; non-toxic; readily available form. FTH1 has ferroxidase activity and is important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Ferritin is composed of 24 subunits of the light and heavy ferritin chains. It plays a role in delivery of iron to cells and mediates iron uptake in capsule cells of the developing kidney. Variation of ferritin subunit composition may affect iron absorption and release in different tissues. Deficiency of ferritin proteins may cause several neurodegenerative diseases. Almost all living organisms can produce this protein; including algae; bacteria; higher plants; and animals.
Product Name:
Human FTH Recombinant Protein (RPES3673)
Product Code:
RPES3673
Size:
10µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
Ferritin heavy chain,FTH1,FTH,FTHL6,Ferritin H subunit,Cell proliferation-inducing gene 15 protein,FHC,HFE5,PIG15
Accession:
P02794
Sequence:
Met 1-Ser183
Fusion tag:
N-6His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Ferritin heavy chain is produced by our E.coli expression system and the target gene encoding Met1-Ser183 is expressed with a 6His tag at the N-terminus.
Purity:
> 90 % as determined by reducing SDS-PAGE.
Mol Mass:
23.4 kDa
AP Mol Mass:
22 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM PB; 150mM NaCl; pH 7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
