Recombinant Human FTH Protein (RPES3650)

SKU:
RPES3650
€68

Description

ELISA Kit Technical Manual

Recombinant Human FTH Protein

Background:Ferritin heavy polypeptide 1(FTH1), is a ubiquitous intracellular protein which stores iron in a soluble, non-toxic, readily available form. FTH1 has ferroxidase activity and is important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Ferritin is composed of 24 subunits of the light and heavy ferritin chains. It plays a role in delivery of iron to cells and mediates iron uptake in capsule cells of the developing kidney. Variation of ferritin subunit composition may affect iron absorption and release in different tissues. Deficiency of ferritin proteins may cause several neurodegenerative diseases. Almost all living organisms can produce this protein, including algae, bacteria, higher plants, and animals.
Name:Recombinant Human FTH Protein
Size:10µg
Assay Genie SKU:RPES3650
Synonyms:Ferritin heavy chain;FTH1;FTH;FTHL6;Ferritin H subunit;Cell proliferation-inducing gene 15 protein;FHC;HFE5;PIG15
Species:Human
Expression host:E.coli
Sequence:Met 1-Ser183
Accession:P02794
Mol Mass:21.2 kDa
AP Mol Mass:22 kDa
Tag:
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per µg as determined by the LAL method.
Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20'C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.
NCBI Summary:This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:P02794
NCBI GenInfo Identifier:120516
NCBI Gene ID:2495
NCBI Accession:P02794.2
UniProt Secondary Accession:P02794,Q3KRA8, Q3SWW1, B3KNR5,
UniProt Related Accession:P02794
Molecular Weight:
NCBI Full Name:Ferritin heavy chain
NCBI Synonym Full Names:ferritin, heavy polypeptide 1
NCBI Official Symbol:FTH1
NCBI Official Synonym Symbols:FHC; FTH; HFE5; PLIF; FTHL6; PIG15
NCBI Protein Information:ferritin heavy chain
UniProt Protein Name:Ferritin heavy chain
UniProt Synonym Protein Names:Cell proliferation-inducing gene 15 protein
Protein Family:Iron transporter
UniProt Gene Name:FTH1
UniProt Entry Name:FRIH_HUMAN
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Additional Information

Product type:
Recombinant Protein
Host species:
E.coli
Reactivity:
Human
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