Human HSP27/HSPB1 Recombinant Protein (RPES3947)

SKU:
RPES3947
Product type:
Recombinant Protein
Host species:
E.coli
Reactivity:
Human
€499

Description

ELISA Kit Technical Manual

Recombinant Human HSP27/HSPB1 Protein (His Tag)

Background:Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 30 substrates of GZMB have been identified including the key substrate caspase-3, ICAD and Bid. GZMB is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells, and accordingly plays an essential role in immunosurveillance.
Name:Recombinant Human HSP27/HSPB1 Protein (His Tag)
Size:50µg
Assay Genie SKU:RPES3947
Synonyms:CMT2F;HEL-S02;HMN2B;HS.76067;Hsp25;HSP27;HSP28;SRP27
Species:Human
Expression host:E.coli
Sequence:Met 1-Lys205
Accession:NP_001531.1
Mol Mass:28 kDa
AP Mol Mass:28 kDa
Tag:C-His
Purity:> 97 % as determined by reducing SDS-PAGE.
Endotoxin:Please contact us for more information.
Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20'C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from sterile 20mM HEPES, 0.1M KCl, pH 7.5
Reconstitution:Please refer to the printed manual for detailed information.