Human HSP27/HSPB1 Recombinant Protein (RPES3947)
- SKU:
- RPES3947
- Product Type:
- Recombinant Protein
- Species:
- Human
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Description
system_update_altDatasheet
Human HSP27/HSPB1 Recombinant Protein
HSP27 is a member of the small heat shock protein family, which also includes HSP25 and the alpha -crystallins. HSP27 forms a large oligomer and the extent of phosphorylation plays a role in determining specific functions. HSP27 also functions as an anti-apoptotic molecule, regulating apoptosis through direct interaction with key components of the apoptotic pathway. HSP27 binds and sequesters cytochrome c released from the mitochondria in response to an apoptotic stimulus. This prevents the proper assembly of the apoptosome and subsequently, the activation of procaspase-9 and procaspase-3.
| Product Name: | Human HSP27/HSPB1 Recombinant Protein (RPES3947) |
| Product Code: | RPES3947 |
| Size: | 50µg |
| Species: | Human |
| Expressed Host: | E.coli |
| Synonyms: | CMT2F,HEL-S-102,HMN2B,HS.76067,Hsp25,HSP27,HSP28,SRP27 |
| Accession: | NP_001531.1 |
| Sequence: | Met 1-Lys205 |
| Fusion tag: | C-His |
| Endotoxin: | Please contact us for more information. |
| Protein Construction: | A DNA sequence encoding the human HSP27 (NP_001531.1) (Met1-Lys205) was expressed with a C-terminal polyhistidine tag. |
| Purity: | > 97 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 28 kDa |
| AP Mol Mass: | 28 kDa |
| Formulation: | Lyophilized from sterile 20mM HEPES, 0.1M KCl, pH 7.5 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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