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Human IL5RA/IL-5 R Alpha Recombinant Protein (RPES2522)

SKU:
RPES2522
Product Type:
Recombinant Protein
Species:
Human
€300
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Description

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Human IL5RA/IL-5 R Alpha Recombinant Protein

Interleukin-5 Receptor alpha (IL-5R?; CD125) is a 60 kDa hematopoietin receptor that plays a dominant role in eosinophil biology. Mature human IL-5 R? consists of a 322 aa extracellular domain (ECD) with a WSxWS motif and a four cysteine motif; a 20 aa transmembrane segment; and a 58 aa cytoplasmic domain. Within the ECD; human IL-5R? shares 71% aa sequence identity with mouse and rat IL-5 R?. Alternate splicing of human IL-5 R? generates soluble secreted forms which function as IL-5 antagonists. The high affinity receptor for IL-5 is a complex that consists of the ligand binding IL-5 R? and the transmembrane common β chain (βc/CD131) which is shared with the receptor complexes for IL-3 and GMCSF. IL-5 R? binds IL-5 at low affinity and then associates with preformed βc oligomers to form the signaling competent receptor complex. IL-5 stimulation of CD34+ hematopoietic progenitor cells induces the up-regulation of transmembrane IL-5R? followed by eosinophilic differentiation and activation.