Interleukin-18 is a secreted protein and it belongs to the IL-1 family. IL-18 is a proinflammatory cytokine that is produced by macrophages and other cells. The IL-18 cytokine can stimulate T-cell IFN-gamma synthesis. The combination of IL-18 and IL12 has been demonstrated to reduce IgE and IgG1 synthesis in B cells, as well as enhance IgG2a production. The interleukin-18 binding protein (IL18BP) can bind specifically to this cytokine, and thus suppress its biological function. Natural killer (NK) cells and certain T cells also release another important cytokine, interferon-gamma (IFN-gamma) or type II interferon, after IL-18 stimulation. The activation of macrophages or other cells by this cytokine is known as type II IFN. Human Interleukin8/IL8 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human Interleukin8/IL8 Recombinant Protein (RPES1650)
Recombinant Human Interleukin-18 is produced by our E.coli expression system and the target gene encoding Tyr37-Asp193 is expressed.
Purity:
> 95% as determined by reducing SDS-PAGE.
Mol Mass:
18.2 kDa
AP Mol Mass:
17 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of PBS; pH7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
