Human LAG3/CD223 Recombinant Protein (RPES2532)
- SKU:
- RPES2532
- Product Type:
- Recombinant Protein
- Species:
- Human
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Description
system_update_altDatasheet
Human LAG3/CD223 Recombinant Protein
LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells. It also acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signalling, leading to increased antigen-specific T-cell responses in vivo.Immune CheckpointImmune Checkpoint Targets Co-inhibitory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy
| Product Name: | Human LAG3/CD223 Recombinant Protein (RPES2532) |
| Product Code: | RPES2532 |
| Size: | 50µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | Lymphocyte activation gene 3 protein,LAG3,LAG-3,Protein FDC,CD223,LAG-3 |
| Accession: | NP_002277.4 |
| Sequence: | Met 1-Leu450 |
| Fusion tag: | C-Fc |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human LAG3 (NP_002277.4) (Met1-Leu450) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Purity: | > (3.0+91.0+3.1) % as determined by reducing SDS-PAGE.. |
| Mol Mass: | 72.3 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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