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Human LAG3/CD223 Recombinant Protein (RPES1159)

SKU:
RPES1159
Product Type:
Recombinant Protein
Species:
Human
€212
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Description

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Human LAG3/CD223 Recombinant Protein

Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.

Product Name:Human LAG3/CD223 Recombinant Protein (RPES1159)
Product Code:RPES1159
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Lymphocyte activation gene 3 protein,LAG3,LAG-3,Protein FDC,CD223,LAG-3
Accession:NP_002277.4
Sequence:Leu23-Gly434
Fusion tag:C-6His
Activity:Immobilized Human FGL1-mFc(Cat: PKSH033679) at 5µg/ml(100 ?l/well) can bind Human LAG-3-His. The ED50 of Human LAG-3-His is 2172.8 ng/mL.
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Lymphocyte Activation Gene 3 Protein is produced by our Mammalian expression system and the target gene encoding Leu23-Gly434 is expressed with a 6His tag at the C-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:45.5 kDa
AP Mol Mass:60-80 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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