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Human LILRA2/ILT1 Recombinant Protein (RPES3402)

SKU:
RPES3402
Product type:
Recombinant Protein
Host species:
Human Cells
Reactivity:
Human
€142

Description

ELISA Kit Technical Manual

Recombinant Human LILRA2/ILT1 Protein (His Tag)

Background:Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 2 (LILRA2) is a single-pass type I membrane protein. LILRA2 is expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. LILRA2 contains four Ig-like C2-type domains, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. LILRA2 does not bind class I MHC antigens.
Name:Recombinant Human LILRA2/ILT1 Protein (His Tag)
Size:10µg
Assay Genie SKU:RPES3402
Synonyms:Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 2; CD85 Antigen-Like Family Member H; Immunoglobulin-Like Transcript 1; ILT; Leukocyte Immunoglobulin-Like Receptor 7; LIR-7; CD85h; LILRA2; ILT1; LIR7
Species:Human
Expression host:Human Cells
Sequence:Gly24-Ser420
Accession:Q8N149
Mol Mass:44.8 kDa
AP Mol Mass:66 kDa
Tag:C-6His
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per µg as determined by the LAL method.
Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20'C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from a 0.2 um filtered solution of 20mM PB,150mM NaCl,pH7.4.
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:LILRA2: Does not bind class I MHC antigens. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: extracellular region; integral to membrane

Molecular Function:receptor activity; antigen binding

Biological Process: immune system process; defense response; signal transduction

NCBI Summary:This gene encodes a member of a family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The encoded protein is an activating receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses innate immune response. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and there is a pseudogene for this gene on chromosome 3. [provided by RefSeq, Mar 2014]
UniProt Code:Q8N149
NCBI GenInfo Identifier:37537906
NCBI Gene ID:11027
NCBI Accession:Q8N149.2
UniProt Secondary Accession:Q8N149,O75020,
UniProt Related Accession:Q8N149
Molecular Weight:483
NCBI Full Name:Leukocyte immunoglobulin-like receptor subfamily A member 2
NCBI Synonym Full Names:leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
NCBI Official Symbol:LILRA2  
NCBI Official Synonym Symbols:ILT1; LIR7; CD85H; LIR-7  
NCBI Protein Information:leukocyte immunoglobulin-like receptor subfamily A member 2; immunoglobulin-like transcript 1; CD85 antigen-like family member H; leukocyte immunoglobulin-like receptor 7; leukocyte immunoglobulin-like receptor subfamily A member 2 soluble
UniProt Protein Name:Leukocyte immunoglobulin-like receptor subfamily A member 2
UniProt Synonym Protein Names:CD85 antigen-like family member H; Immunoglobulin-like transcript 1; ILT; Leukocyte immunoglobulin-like receptor 7; LIR-7; CD_antigen: CD85h
Protein Family:Leukocyte immunoglobulin-like receptor subfamily
UniProt Gene Name:LILRA2  
UniProt Entry Name:LIRA2_HUMAN