Prolactin (PRL) is a neuroendocrine pituitary hormone that acts mainly on the mammary gland to stimulate lactation, but it also has pleiotropic effects in males and females. Non-glycosylated prolactin is created in the pituitary and held in storage granules before release, while glycosylated prolactin is said to be constantly secreted. Prolactin is made in the anterior pituitary in all mammal species, and its production is regulated by tonic inhibition from the hypothalamus. Prolactin is formed peripherally in humans as well. Prolactin expression is minimal in early pregnancy and rises later on. The prolactin receptor (PRLR) is a cytokine hematopoietic receptor protein. It's thought that the prolactin molecule binds to two receptor molecules. In addition to its lactogenic activity; peripherally produced prolactin plays roles in breast and prostate cancer development; regulation of reproductive function; and immunoregulation. Human Prolactin/PRL Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human Prolactin/PRL Recombinant Protein (RPES0285)
Product Code:
RPES0285
Size:
10µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
Prolactin, PRL
Accession:
P01236
Sequence:
Leu29-Cys227
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Prolactin is produced by our E.coli expression system and the target gene encoding Leu29-Cys227 is expressed.
Purity:
> 95% as determined by reducing SDS-PAGE.
Mol Mass:
23 kDa
AP Mol Mass:
25 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM PB; 150mM Nacl; 1mM EDTA; pH7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
