S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and their name is based on the fact that the protein is completely soluble in ammonium sulfate at neutral pH. The majority of S100 proteins are homodimers that form by linking disulfide bonds, and they may be found in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, and other cell types. S100 proteins have been linked to a variety of intracellular and extracellular activities. They regulate protein phosphorylation, transcription factors, cytoskeleton components' dynamics, enzyme activities, cell growth and development, and the inflammatory response. Protein S100-A12, also known as S100 calcium-binding protein A12, Calcium-binding protein in amniotic fluid 1, Calgranulin-C, and S100A12, is a member of the S-101 family. S100A12, like the majority of S100 proteins, is a dimer with a hydrophobic contact interface between the two subunits. The fold of S100A12 is comparable to that of other known S100 protein crystal and solution structures, with the exception of the linker region connecting the two EF-hand motifs. S100A12 plays an important role in the inflammatory response. Human S100A12/CAGC Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human S100A12/CAGC Recombinant Protein (RPES3336)
Product Code:
RPES3336
Size:
50µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
Protein S100-A12,Calcium-binding protein in amniotic fluid 1,Calgranulin-C,Extracellular newly identified RAGE-binding protein,Migration inhibitory factor-related protein 6,S100 calcium-binding protein A12,Calcitermin,S100A12,CGRP,MRP-6,EN-RAGE
Accession:
NP_005612.1
Sequence:
Met 1-Glu 92
Fusion tag:
Activity:
Measured by its binding ability in a functional ELISA. Immobilized recombinant human S100A12 at 2 µg/ml (100 ?l/well) can bind human AGER with a linear range of 0.032-20 µg/ml.
Endotoxin:
Please contact us for more information.
Protein Construction:
A DNA sequence encoding the native human S100A12 (NP_005612.1) (Met 1-Glu 92) was expressed.
Purity:
> 98 % as determined by reducing SDS-PAGE.
Mol Mass:
10.6 kDa
AP Mol Mass:
10 kDa
Formulation:
Lyophilized from sterile PBS, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
