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Key Features

Recombinant Keap1 Monoclonal Antibody (AGEL8596)

Datasheet MSDS
SKU AGEL8596
Product Type Antibody
Reactivity Human, Mouse
Applications WB, IHC-P
Host Species Rabbit
Clonality Monoclonal
Clone C223291
Conjugate Unconjugated
$461 - $632

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Description

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Recombinant Keap1 Monoclonal Antibody

The Recombinant Keap1 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C223291) against Keap1. KEAP1, also named as INRF2, KIAA0132 and KLHL19, is part of a multiprotein complex that contains the CUL3-ROC1 ubiquitin ligase, which can ubiquitinate the N-terminal domain of NRF2. Two molecules of KEAP1 bind to two distinct sites in the N-terminal region of NRF2, the ETGE and DLG sites, which affect the KEAP1-NRF2 interaction and/or its physiological consequences. KEAP1 retains NFE2L2/NRF2 in the cytosol. Produced by recombinant technology in Rabbit hosts and purified by affinity chromatography, this Rabbit IgG antibody is reactive against Human and Mouse samples.

This antibody is suitable for WB and IHC-P applications. It has been validated by WB analysis of Hela, A549, C2C12 and IHC analysis of Human breast cancer. The target is localized to the Cytoplasm. Nucleus. Shuttles between cytoplasm and nucleus.

Product Name:Recombinant Keap1 Monoclonal Antibody
SKU:AGEL8596
Size:50 µL, 100 µL
Antibody Type:Recombinant Monoclonal Antibody
Synonyms:Cytosolic inhibitor of Nrf2, INrf 2, INrf2, Keap 1, KEAP1, Kelch like ECH associated protein 1, Kelch like family member 19, Kelch like protein 19, Kelch-like ECH-associated protein 1, Kelch-like protein 19, KIAA0132, KLHL 19, KLHL19, M, MGC10630, MGC1114, MGC20887, MGC4407, MGC9454
Reactivity:Human, Mouse
Immunogen:Recombinant protein of human Keap1
Applications:WBIHC-P
Clonality:Recombinant Monoclonal
Clone No:C223291
Host:Rabbit
Isotype:Rabbit IgG
Target:Keap1
Conjugation:Unconjugated
Observed MW:60/64 kDa
Calculated MW:70 kDa
Recommended Dilution:WB 1:500-1000; IHC 1:20-50
UniProt:Q14145
Purification:Affinity purification
Concentration:0.3 mg/mL
Buffer:50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% stabilizer and 0.05% protective protein.
Storage:Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
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