The Recombinant Laminin beta 1 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C241208) against Laminin beta 1. Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human and Mouse samples.
This antibody is suitable for IHC, IF and FCM applications. It has been validated by IHC analysis of Human placenta, IF analysis of NIH-3T3 and FCM analysis of A431. The target is localized to the basement membrane.