The Recombinant LDLR Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C111025) against LDLR. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.
This antibody is suitable for WB, IHC, IF and ELISA applications. It has been validated by IHC analysis of Mouse liver. The target is localized to the cell membrane, Single-pass type I membrane protein, membrane, clathrin-coated pit, Golgi apparatus, early endosome, late endosome, lysosome, rapidly endocytosed upon ligand binding.
