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Recombinant Neutrophil Elastase Monoclonal Antibody (AGEL6800)

Datasheet MSDS
SKU AGEL6800
Product Type Antibody
Reactivity Human
Applications WB
Host Species Rabbit
Clonality Monoclonal
Clone C331495
Conjugate Unconjugated
€459 - €639

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Description

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Recombinant Neutrophil Elastase Monoclonal Antibody

The Recombinant Neutrophil Elastase Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C331495) against Neutrophil Elastase. Neutrophil Elastase is hematopoietic serine protease that belongs to the chymotrypsin superfamily and plays a critical role in the innate immune function of mature neutrophils and monocytes. Neutrophil elastase is actively synthesized as an inactive zymogen in myelocytic precursor cells of the bone marrow, which then undergoes activation by limited proteolysis and sorting to primary (azurophil) storage granules of mature neutrophil granulocytes for regulated release. Research studies have shown that neutrophils play a significant role in mediating the inflammatory response through the release of neutrophil elastase, which activates pro-inflammatory cytokines and degrades components of the extracellular matrix and Gram-negative bacteria. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human samples.

This antibody is suitable for WB applications. It has been validated by WB analysis of THP-1, HL-60. The target is localized to the phagosome.

Product Name:Recombinant Neutrophil Elastase Monoclonal Antibody
SKU:AGEL6800
Size:50 µL, 100 µL
Antibody Type:Recombinant Monoclonal Antibody
Synonyms:Bone marrow serine protease, ELA, ELA2, ELANE, Elastase, Elastase 2, Elastase 2 neutrophil, Elastase neutrophil expressed, Elastase-2, ELNE, GE, Granulocyte derived elastase, HLE, HNE, Human leukocyte elastase, Leukocyte elastase, Medullasin, NE, Neutrophil elastase, Neutrophil expressed, PMN E, PMN elastase, PMN-E, Polymorphonuclear elastase, SCN, SCN1
Reactivity:Human
Immunogen:Recombinant human Neutrophil Elastase fragment
Applications:WB
Clonality:Recombinant Monoclonal
Clone No:C331495
Host:Rabbit
Isotype:Rabbit IgG
Target:Neutrophil Elastase
Conjugation:Unconjugated
Observed MW:29 kDa
Calculated MW:29 kDa
Recommended Dilution:WB 1:1000-5000
UniProt:P08246
Purification:Protein A
Concentration:1 mg/mL
Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
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