The Recombinant NSD3 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C331647) against NSD3. Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), also known as histone-lysine N-methyltransferase NSD3, is a SET domaincontaining histone methyltransferase protein that methylates histone H3 on lysine 4 (H3K4me) and lysine 27 (H3K27me) (1). Methylation of histone H3 lysine 4 is associated with transcriptional activation, while methylation of histone H3 lysine 27 is associated with transcriptional repression. WHSC1L1 can function as an oncogene or a tumor suppressor protein, depending on cell context, and has been shown to regulate expression of a number of genes associated with cell cycle (2). Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human samples.
This antibody is suitable for WB applications. It has been validated by WB analysis of TH-29 (Low expression),?MOLT-4. The target is localized to the nucleus.
![Anti-NSD3 [R05-3D1] Monoclonal Antibody (AGMB00296)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/590x590/products/271585/694620/anti-nsd3-r05-3d1-monoclonal-antibody-agmb00296__05511.1774513046.jpg?c=2 "Anti-NSD3 [R05-3D1] Monoclonal Antibody (AGMB00296)")
