The Recombinant Paxillin Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C723379) against Paxillin. This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). Produced by recombinant technology in Rabbit hosts and purified by affinity chromatography, this Rabbit IgG antibody is reactive against Human, Rat and Hamster samples.
This antibody is suitable for WB and IHC-P applications. It has been validated by WB analysis of CHO-K1, C6 and IHC analysis of Human breast cancer. The target is localized to the Cytoplasm>cytoskeleton. Cell junction>focal adhesion.