The Recombinant PELP1 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C311248) against PELP1. Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human samples.
This antibody is suitable for WB, IHC-P, ICC/IF and FC applications. It has been validated by WB analysis of HeLa, MCF-7, HepG2, IHC analysis of Human breast and IF analysis of HeLa. The target is localized to the cytoplasm, nucleus.