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Recombinant Phospho-IRF3 (Ser396) Monoclonal Antibody (AGEL6318)

Datasheet MSDS
SKU AGEL6318
Product Type Antibody
Reactivity Human, Mouse
Applications WB, IF, ELISA
Host Species Rabbit
Clonality Monoclonal
Clone C271012
Conjugate Unconjugated
€409 - €559

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Description

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Recombinant Phospho-IRF3 (Ser396) Monoclonal Antibody

The Recombinant Phospho-IRF3 (Ser396) Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C271012) against IRF3 (Ser396). This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human and Mouse samples.

This antibody is suitable for WB, IF and ELISA applications. It has been validated by WB analysis of Hela. The target is localized to the cytoplasm, nucleus, mitochondrion, shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect (PubMed:10805757). When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm (PubMed:10805757). Recruited to mitochondria via TOMM70:HSP90AA1 upon Sendai virus infection (PubMed:25609812).

Product Name:Recombinant Phospho-IRF3 (Ser396) Monoclonal Antibody
SKU:AGEL6318
Size:50 µL, 100 µL
Antibody Type:Recombinant Monoclonal Antibody
Synonyms:entrez:3661, IIAE7, IRF, IRF-3, IRF3
Reactivity:Human, Mouse
Immunogen:A synthetic peptide corresponding to residues around (Ser396) of Human Phospho-IRF3
Applications:WBIFELISA
Clonality:Recombinant Monoclonal
Clone No:C271012
Host:Rabbit
Isotype:Rabbit IgG
Target:IRF3 (Ser396)
Conjugation:Unconjugated
Observed MW:60 kDa
Calculated MW:47 kDa
Recommended Dilution:WB 1:500-2000; IF 1:200-1000; ELISA 1:5000-20000
UniProt:Q14653
Purification:Protein A
Concentration:0.2 mg/mL
Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
Product ImageWestern Blot with Recombinant Phospho-IRF3 (Ser396) Monoclonal Antibody at dilution of 1:1000 dilution. Lane A: Hela lysate. Observed-MW:60 kDa Calculated-MW:47 kDa
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