The Recombinant Phospho-IRF3 (Ser386) Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C371007) against IRF3 (Ser386). This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human samples.
This antibody is suitable for WB, IF and ELISA applications. It has been validated by WB analysis of Hela. The target is localized to the cytoplasm, nucleus, mitochondrion, shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect (PubMed:10805757). When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm (PubMed:10805757). Recruited to mitochondria via TOMM70:HSP90AA1 upon Sendai virus infection (PubMed:25609812).
![Anti-Phospho-IRF3 (Ser386) [R05-2Q2] Monoclonal Antibody (AGMB05065)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/590x590/products/276350/676482/anti-phospho-irf3-ser386-r05-2q2-monoclonal-antibody-agmb05065__53130.1773029552.jpg?c=2 "Anti-Phospho-IRF3 (Ser386) [R05-2Q2] Monoclonal Antibody (AGMB05065)")
