The Recombinant Phospho-PAK1 (Thr212) Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C231721) against PAK1 (Thr212). The p21-activated kinase (PAK) family of serine/threonine kinases is engaged in multiple cellular processes, including cytoskeletal reorganization, MAPK signaling, apoptotic signaling, control of phagocyte NADPH oxidase, and growth factor-induced neurite outgrowth. Several mechanisms that induce PAK activity have been reported. Binding of Rac/Cdc42 to the CRIB (or PBD) domain near the amino terminus of PAK causes autophosphorylation and conformational changes in PAK. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human and Mouse samples.
This antibody is suitable for WB applications. It has been validated by WB analysis of SH-SY5Y, 4T1, NIH-3T3. The target is localized to the cell membrane, nucleus, cytoplasm.
