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Recombinant SIRT6 Monoclonal Antibody (AGEL6762)

Datasheet MSDS
SKU AGEL6762
Product Type Antibody
Reactivity Human, Rat, Mouse
Applications WB
Host Species Rabbit
Clonality Monoclonal
Clone C131457
Conjugate Unconjugated
$606 - $843

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Description

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Recombinant SIRT6 Monoclonal Antibody

The Recombinant SIRT6 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C131457) against SIRT6. SirT6, a mammalian homolog of Sir2, is a nuclear, chromatin-associated protein that promotes the normal maintenance of genome integrity mediated by the base excision repair (BER) pathway. The BER pathway repairs single-stranded DNA lesions that arise spontaneously from endogenous alkylation, oxidation, and deamination events. SirT6 deficient mice show increased sensitivity to DNA-damaging agents, including the alkylating agents MMS and H2O2. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.

This antibody is suitable for WB applications. It has been validated by WB analysis of HCT-116, HeLa, Jurkat, C2C12, PC-12. The target is localized to the nucleus, endoplasmic reticulum.

Product Name:Recombinant SIRT6 Monoclonal Antibody
SKU:AGEL6762
Size:50 µL, 100 µL
Antibody Type:Recombinant Monoclonal Antibody
Synonyms:SIR2L, SIR2L6, SIRT, SIRT6, sirtuin, sirtuin 6
Reactivity:Human, Mouse, Rat
Immunogen:Recombinant human SIRT6 fragment
Applications:WB
Clonality:Recombinant Monoclonal
Clone No:C131457
Host:Rabbit
Isotype:Rabbit IgG
Target:SIRT6
Conjugation:Unconjugated
Observed MW:42 kDa
Calculated MW:39 kDa
Recommended Dilution:WB 1:500-1000
UniProt:Q8N6T7
Purification:Protein A
Concentration:1 mg/mL
Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
Product ImageWestern Blot with SIRT6 Monoclonal Antibody at dilution of 1:1000. Lane 1: HCT-116, Lane 2: HeLa, Lane 3: Jurkat, Lane 4: C2C12, Lane 5: PC-12 Observed-MW:42 kDa Calculated-MW:39 kDa
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