The Recombinant SOCS3 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C531624) against SOCS3. The suppressor of cytokine signaling (SOCS) family members are negative regulators of cytokine signal transduction that inhibit the Jak/Stat pathway. The SOCS family consists of at least 8 members including the originally identified cytokine-inducible SH2-containing protein (CIS1), as well as SOCS1-7. Each SOCS family member contains a central SH2 domain and a conserved carboxy-terminal motif designated as the SOCS box. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Mouse samples.
This antibody is suitable for WB applications. It has been validated by WB analysis of RAW264.7,?RAW264.7+LPS(10 ng, ml 48h). The target is localized to the cytoplasmic side of plasma membrane.
