The Recombinant Tissue Plasminogen Activator Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C721626) against Tissue Plasminogen Activator. Plasminogen activator, tissue (PLAT, synonyms: TPA, T-PA) is a tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein (33 kDa and 32 kDa). PLAT enzyme plays a role in cell migration and tissue remodeling. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human and Rat samples.
This antibody is suitable for WB and IHC applications. It has been validated by WB analysis of Human liver, Rat plasma and IHC analysis of Human liver. The target is localized to the secreted.