Anti-RMI2 Antibody (CAB8523)
- SKU:
- CAB8523
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Antibody Name: | Anti-RMI2 Antibody |
| Antibody SKU: | CAB8523 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human RMI2 (NP_689521.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HeLa, MCF7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human RMI2 (NP_689521.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAA ADSF SGGP AGVR LPRS PPLK VLAE QLRR DAEG GPGA WRLS RAAA GRGP LDLA AVWM QGRV VMAD RGEA RLRD PSGD FSVR GLER VPRG RPCL VPGK YVMV MGVV QACS PEPC LQAV KMTD LSDN PIHE SMWE LEVE DLHR NIP |
| Gene ID: | 116028 |
| Uniprot: | Q96E14 |
| Cellular Location: | Nucleus |
| Calculated MW: | 9kDa/15kDa |
| Observed MW: | 16kDa |
| Synonyms: | RMI2, BLAP18, C16orf75 |
| Background: |
| UniProt Protein Function: | Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM. |
| NCBI Summary: | RMI2 is a component of the BLM (RECQL3; MIM 604610) complex, which plays a role in homologous recombination-dependent DNA repair and is essential for genome stability (Xu et al., 2008 [PubMed 18923082]).[supplied by OMIM, Nov 2008] |
| UniProt Code: | Q96E14 |
| NCBI GenInfo Identifier: | 24308245 |
| NCBI Gene ID: | 116028 |
| NCBI Accession: | NP_689521.1 |
| UniProt Secondary Accession: | Q96E14,Q49AE2, Q8TBL0, B3KVZ6, |
| UniProt Related Accession: | Q96E14 |
| Molecular Weight: | 9,262 Da |
| NCBI Full Name: | recQ-mediated genome instability protein 2 |
| NCBI Synonym Full Names: | RecQ mediated genome instability 2 |
| NCBI Official Symbol: | RMI2Â Â |
| NCBI Official Synonym Symbols: | BLAP18; C16orf75Â Â |
| NCBI Protein Information: | recQ-mediated genome instability protein 2 |
| UniProt Protein Name: | RecQ-mediated genome instability protein 2 |
| UniProt Synonym Protein Names: | BLM-associated protein of 18 kDa; BLAP18 |
| Protein Family: | RecQ-mediated genome instability protein |
| UniProt Gene Name: | RMI2Â Â |
 | Western blot analysis of extracts of various cell lines, using RMI2 antibody (CAB8523) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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