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Anti-RNASE3 Antibody (CAB1854)

SKU:
CAB1854
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
  • Cell Biology Antibodies 7 Anti-RNASE3 Antibody CAB1854
  • Cell Biology Antibodies 7 Anti-RNASE3 Antibody CAB1854
€139 - €419
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Description

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Antibody Name:Anti-RNASE3 Antibody
Antibody SKU:CAB1854
Antibody Size:20uL, 50uL, 100uL
Application:IHC
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 28-160 of human RNASE3 (NP_002926.2).
Application:IHC
Recommended Dilution:IHC 1:50 - 1:100
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 28-160 of human RNASE3 (NP_002926.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RPPQ FTRA QWFA IQHI SLNP PRCT IAMR AINN YRWR CKNQ NTFL RTTF ANVV NVCG NQSI RCPH NRTL NNCH RSRF RVPL LHCD LINP GAQN ISNC TYAD RPGR RFYV VACD NRDP RDSP RYPV VPVH LDTT I
Gene ID:6037
Uniprot:P12724
Cellular Location:Secreted
Calculated MW:18kDa
Observed MW:
Synonyms:RNASE3, ECP, RAF1, RNS3
Background:The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria
UniProt Protein Function:RNASE3: Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. Belongs to the pancreatic ribonuclease family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide; EC 3.1.27.-; Ribonuclease

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: extracellular space; extracellular region

Molecular Function:nucleic acid binding; endonuclease activity; ribonuclease activity

Biological Process: defense response to Gram-positive bacterium; innate immune response in mucosa; RNA catabolic process; antibacterial humoral response

NCBI Summary:The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014]
UniProt Code:P12724
NCBI GenInfo Identifier:147744558
NCBI Gene ID:6037
NCBI Accession:P12724.2
UniProt Secondary Accession:P12724,Q4VBC1, Q8WTP7, Q8WZ62, Q9GZN9,
UniProt Related Accession:P12724
Molecular Weight:18kDa
NCBI Full Name:Eosinophil cationic protein
NCBI Synonym Full Names:ribonuclease, RNase A family, 3
NCBI Official Symbol:RNASE3  
NCBI Official Synonym Symbols:ECP; RNS3  
NCBI Protein Information:eosinophil cationic protein; RNase 3; ribonuclease 3; cytotoxic ribonuclease
UniProt Protein Name:Eosinophil cationic protein
UniProt Synonym Protein Names:Ribonuclease 3; RNase 3
Protein Family:Eosinophil cationic protein
UniProt Gene Name:RNASE3  
UniProt Entry Name:ECP_HUMAN
Anti-RNASE3 Antibody (CAB1854)Immunohistochemistry of paraffin-embedded human colon using RNASE3 antibody (CAB1854) at dilution of 1:100 (40x lens).
Anti-RNASE3 Antibody (CAB1854)Immunohistochemistry of paraffin-embedded human stomach using RNASE3 antibody (CAB1854) at dilution of 1:100 (40x lens).

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