RPA70 Rabbit Polyclonal Antibody (CAB9841)
- SKU:
- CAB9841
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
Product Name: | RPA70 Rabbit Polyclonal Antibody |
SKU: | CAB9841 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 274-533 of human RPE65 (NP_000320.1). |
Sequence: | NYMD CFES NETM GVWL HIAD KKRK KYLN NKYR TSPF NLFH HINT YEDN GFLI VDLC CWKG FEFV YNYL YLAN LREN WEEV KKNA RKAP QPEV RRYV LPLN IDKA DTGK NLVT LPNT TATA ILCS DETI WLEP EVLF SGPR QAFE FPQI NYQK YCGK PYTY AYGL GLNH FVPD RLCK LNVK TKET WVWQ EPDS YPSE PIFV SHPD ALEE DDGV VLSV VVSP GAGQ KPAY LLIL NAKD LSEV ARAE VEIN IPVT FHGL FKKS |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 IF/ICC,1:50 - 1:200 |
Synonyms: | p63; BCO3; LCA2; RP20; rd12; mRPE65; sRPE65; RPE65 |
Positive Sample: | Mouse eye |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Lipid-anchor, Microsome membrane. |
Calculated MW: | 61kDa |
Observed MW: | 65kDa |
The protein encoded by this gene is a component of the vitamin A visual cycle of the retina which supplies the 11-cis retinal chromophore of the photoreceptors opsin visual pigments. It is a member of the carotenoid cleavage oxygenase superfamily. All members of this superfamily are non-heme iron oxygenases with a seven-bladed propeller fold and oxidatively cleave carotenoid carbon:carbon double bonds. However, the protein encoded by this gene has acquired a divergent function that involves the concerted O-alkyl ester cleavage of its all-trans retinyl ester substrate and all-trans to 11-cis double bond isomerization of the retinyl moiety. As such, it performs the essential enzymatic isomerization step in the synthesis of 11-cis retinal. Mutations in this gene are associated with early-onset severe blinding disorders such as Leber congenital.
Purification Method: | Affinity purification |
Gene ID: | 6121 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |