The SCRIB Antibody (CAB17450) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, has high reactivity with Scrib in human samples and is validated for use in Western blot applications. By binding to Scrib, this antibody allows for the detection and analysis of this protein in various cell types, making it ideal for studies in cell biology and cancer research.Scrib is a key player in cell polarity, which is essential for proper cell division and tissue organization. Dysregulation of Scrib has been implicated in various types of cancer, making it an important target for research aimed at understanding cancer development and progression.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
SCRIB Antibody
SKU:
CAB17450
Size:
20μL, 100μL
Reactivity:
Human
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
Purification Method
Affinity purification
Gene ID
23513
RRID
AB_2772164
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of lysates from MCF7 cells, using SCRIB Rabbit pAb (CAB17450) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
