Serrumab Antibody is a research-grade biosimilar monoclonal antibody targeting Tityustoxin VIIToxin VIITs7. It is a human IgG1, kappa antibody. Reactivity: Tityus serrulatus (Brazilian scorpion). Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.
Beta-mammal/insect toxin Ts1 (Tityustoxin VIIToxin VIITs7) is a ~9 kDa protein. Voltage-gated sodium channels (Nav) gating-modifier. Acts both as alpha- and beta-toxin, since it affects not only activation but also inactivation of Nav channels (Probable). Binds to Nav domain DII and impairs the four Nav channel voltage sensors movements. Depending on Nav channel subtypes tested, can also bind Nav domains DIII (low affinity) and DIV (very low affinity). Acts on almost all the Nav channels tested (mammalian Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.6/SCN8A, Nav1.9/SCN11A, and insect DmNav1).
Product Name:
Serrumab Antibody
SKU:
GXBS02029
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Target:
Tityustoxin VIIToxin VIITs7
Isotype:
IgG1, kappa
Host Species:
Human
Reactivity:
Tityus serrulatus (Brazilian scorpion)
Applications:
ELISA, FACS, Functional assay, Research in vivo
Expression Host:
Mammalian cells
Purity:
>95% purity as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4
State of Matter:
Liquid
Regulatory Status:
For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
