Anti-SF3A1 Antibody (CAB4399)
- SKU:
- CAB4399
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- SF3A1
- PRP21
- PRPF21
- SAP114
- SF3A120
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Product Name: | SF3A1 Rabbit pAb |
| Product Code: | CAB4399 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | SF3A1, PRP21, PRPF21, SAP114, SF3A120 |
| Applications: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 443-793 of human SF3A1 (NP_005868.1). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:1000 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse lung, Rat brain, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 443-793 of human SF3A1 (NP_005868.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DRSI REKQ SDDE VYAP GLDI ESSL KQLA ERRT DIFG VEET AIGK KIGE EEIQ KPEE KVTW DGHS GSMA RTQQ AAQA NITL QEQI EAIH KAKG LVPE DDTK EKIG PSKP NEIP QQPP PPSS ATNI PSSA PPIT SVPR PPTM PPPV RTTV VSAV PVMP RPPM ASVV RLPP GSVI APMP PIIH APRI NVVP MPPS APPI MAPR PPPM IVPT AFVP APPV APVP APAP MPPV HPPP PMED EPTS KKLK TEDS LMPE EEFL RRNK GPVS IKVQ VPNM QDKT EWKL NGQV LVFT LPLT DQVS VIKV KIHE ATGM PAGK QKLQ YEGI FIKD SNSL AYYN MANG AVIH LALK ERGG RKK |
| Gene ID: | 10291 |
| Uniprot: | Q15459 |
| Cellular Location: | Nucleus |
| Calculated MW: | 81kDa/88kDa |
| Observed MW: | 130kDa |
| UniProt Protein Function: | SF3A1: subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. |
| UniProt Protein Details: | Protein type:RNA-binding; Nuclear receptor co-regulator; Spliceosome; RNA splicing Chromosomal Location of Human Ortholog: 22q12.2 Cellular Component: nucleoplasm; spliceosome Molecular Function:protein binding; RNA binding Biological Process: nuclear mRNA 3'-splice site recognition; nuclear mRNA splicing, via spliceosome; RNA splicing; gene expression; mRNA processing |
| NCBI Summary: | This gene encodes a subunit of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer is a component of the mature U2 small nuclear ribonucleoprotein particle (snRNP). U2 small nuclear ribonucleoproteins play a critical role in spliceosome assembly and pre-mRNA splicing. [provided by RefSeq, Aug 2014] |
| UniProt Code: | Q15459 |
| NCBI GenInfo Identifier: | 2498882 |
| NCBI Gene ID: | 10291 |
| NCBI Accession: | Q15459.1 |
| UniProt Related Accession: | Q15459 |
| Molecular Weight: | |
| NCBI Full Name: | Splicing factor 3A subunit 1 |
| NCBI Synonym Full Names: | splicing factor 3a subunit 1 |
| NCBI Official Symbol: | SF3A1Â Â |
| NCBI Official Synonym Symbols: | PRP21; PRPF21; SAP114; SF3A120Â Â |
| NCBI Protein Information: | splicing factor 3A subunit 1 |
| UniProt Protein Name: | Splicing factor 3A subunit 1 |
| UniProt Synonym Protein Names: | SF3a120; Spliceosome-associated protein 114; SAP 114 |
| Protein Family: | Splicing factor |
| UniProt Gene Name: | SF3A1Â Â |
| UniProt Entry Name: | SF3A1_HUMAN |
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