SIRPB1 Antibody (PACO00549)
- SKU:
- PACO00549
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SIRPB1 Antibody |
Antibody SKU: | PACO00549 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:2000 |
Species Reactivity: | Human |
Immunogen: | synthesized peptide derived from the Internal region of human CD172b. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | SIRPB1; Signal-regulatory protein beta-1; SIRP-beta-1; CD172 antigen-like family member B; CD antigen CD172b |
UniProt Protein Function: | SIRPB1: Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 20p13Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: protein bindingBiological Process: cell surface receptor linked signal transduction; innate immune response; signal transduction |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] |
UniProt Code: | O00241 |
NCBI GenInfo Identifier: | 311033545 |
NCBI Gene ID: | 10326 |
NCBI Accession: | O00241.5 |
UniProt Secondary Accession: | O00241,Q5TFQ9, Q5TFR0, Q8TB12, Q9H1U5, Q9Y4V0, A6NLM2 B2R8V0 |
UniProt Related Accession: | O00241,Q5TFQ8, O00241 |
Molecular Weight: | 43,359 Da |
NCBI Full Name: | Signal-regulatory protein beta-1 |
NCBI Synonym Full Names: | signal regulatory protein beta 1 |
NCBI Official Symbol: | SIRPB1Â Â |
NCBI Official Synonym Symbols: | CD172b; SIRP-BETA-1Â Â |
NCBI Protein Information: | signal-regulatory protein beta-1 |
UniProt Protein Name: | Signal-regulatory protein beta-1 |
UniProt Synonym Protein Names: | CD172 antigen-like family member B; CD_antigen: CD172b |
Protein Family: | Signal-regulatory protein |
UniProt Gene Name: | SIRPB1Â Â |
UniProt Entry Name: | SIRB1_HUMAN |