The SLC2A11 Antibody (PAC018005) is a polyclonal antibody designed for research involving SLC2A11, a cell membrane transporter protein responsible for glucose transport. This antibody is raised in rabbits and is highly reactive with human samples, making it ideal for use in Western blot applications. By binding specifically to the SLC2A11 protein, this antibody allows for the detection and analysis of glucose transport activity in various cell types, making it a valuable tool for studies in metabolism, diabetes, and other related fields.SLC2A11, also known as GLUT11, plays a crucial role in glucose homeostasis by facilitating the uptake of glucose into cells.
Its importance in regulating glucose transport makes it a key target for research into metabolic disorders, diabetes, and other conditions related to glucose metabolism. Understanding the function of SLC2A11 is essential for developing innovative therapies that target glucose transport and metabolism in disease contexts. This antibody provides researchers with a reliable tool for studying the activity and regulation of SLC2A11, ultimately contributing to advancements in the field of metabolic research.
Antibody Name:
SLC2A11 Antibody (PACO18005)
Antibody SKU:
PACO18005
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human SLC2A11
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO18005(SLC2A11 Antibody) at dilution 1/140, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18005(SLC2A11 Antibody) at dilution 1/140, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Solute carrier family 2, facilitated glucose transporter member 11 (SLC2A11) also known as glucose transporter type 10/11 (GLUT-10/11) is a protein that in humans is encoded by the SLC2A11 gene. SLC2A11 belongs to a family of plasma membrane proteins that mediate transport of sugars across the membrane by facilitative diffusion.
Synonyms:
solute carrier family 2 (facilitated glucose transporter), member 11
UniProt Protein Function:
GLUT11: an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. Three isoforms of the human protein are produced by alternative splicing due to three different first exons that code for three different N-termini of 7, 14 and 10 amino acids. Exon 1-c encodes a dileucine motif that may influence its subcellular localization.Protein type: Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral; TransporterChromosomal Location of Human Ortholog: 22q11.23Cellular Component: plasma membrane; integral to membraneMolecular Function: substrate-specific transmembrane transporter activityBiological Process: carbohydrate transport; transmembrane transport
UniProt Protein Details:
NCBI Summary:
This gene belongs to a family of proteins that mediate the transport of sugars across the cell membrane. The encoded protein transports glucose and fructose. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
