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Anti-ZIP8 Antibody (CAB10395)

SKU:
CAB10395
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
  • Signal Transduction Antibodies 1 Anti-ZIP8 Antibody CAB10395
  • Signal Transduction Antibodies 1 Anti-ZIP8 Antibody CAB10395
€139 - €419
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Description

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Antibody Name:Anti-ZIP8 Antibody
Antibody SKU:CAB10395
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 180-300 of human ZIP8 (NP_071437.3).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:HL-60, NCI-H460, HeLa, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 180-300 of human ZIP8 (NP_071437.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QLIP EAFG FDPK VDSY VEKA VAVF GGFY LLFF FERM LKML LKTY GQNG HTHF GNDN FGPQ EKTH QPKA LPAI NGVT CYAN PAVT EANG HIHF DNVS VVSL QDGK KEPS SCTC LKGP KLSE I
Gene ID:64116
Uniprot:Q9C0K1
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:43kDa/48kDa/49kDa
Observed MW:50kDa
Synonyms:SLC39A8, BIGM103, CDG2N, LZT-Hs6, PP3105, ZIP8
Background:This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
UniProt Protein Function:SLC39A8: Acts as a zinc-influx transporter. Belongs to the ZIP transporter (TC 2.A.5) family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 4q24

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:zinc ion transmembrane transporter activity

Biological Process: cellular zinc ion homeostasis; zinc ion transport

Disease: Congenital Disorder Of Glycosylation, Type Iin

NCBI Summary:This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Oct 2008]
UniProt Code:Q9C0K1
NCBI GenInfo Identifier:74733496
NCBI Gene ID:64116
NCBI Accession:Q9C0K1.1
UniProt Secondary Accession:Q9C0K1,Q96SM9, Q9BVC0, Q9NSA4, B4E2H3,
UniProt Related Accession:Q9C0K1
Molecular Weight:
NCBI Full Name:Zinc transporter ZIP8
NCBI Synonym Full Names:solute carrier family 39 member 8
NCBI Official Symbol:SLC39A8  
NCBI Official Synonym Symbols:ZIP8; CDG2N; PP3105; BIGM103; LZT-Hs6  
NCBI Protein Information:zinc transporter ZIP8
UniProt Protein Name:Zinc transporter ZIP8
UniProt Synonym Protein Names:BCG-induced integral membrane protein in monocyte clone 103 protein; LIV-1 subfamily of ZIP zinc transporter 6; LZT-Hs6; Solute carrier family 39 member 8; Zrt- and Irt-like protein 8; ZIP-8
Protein Family:Zinc transporter
UniProt Gene Name:SLC39A8  
Anti-ZIP8 Antibody (CAB10395)Western blot analysis of extracts of various cell lines, using ZIP8 antibody (CAB10395) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-ZIP8 Antibody (CAB10395)Immunofluorescence analysis of L929 cells using ZIP8 Rabbit pAb (CAB10395) at dilution of 1:100. Blue: DAPI for nuclear staining.

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