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Anti-SMC1 Antibody (CAB4693)

SKU:
CAB4693
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CDLS2
DXS423E
SB1.8
SMC1
SMC1L1
SMC1alpha
SMCB
Research Area:
Cell Cycle
  • Cell Cycle Antibodies 2 Anti-SMC1 Antibody CAB4693
  • Cell Cycle Antibodies 2 Anti-SMC1 Antibody CAB4693
€139 - €419
Frequently bought together:

Description

Product Name:SMC1 Rabbit mAb
Product Code:CAB4693
Size:20uL, 50uL, 100uL
Synonyms:CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB
Applications:WB, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human SMC1
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, 293T, Jurkat, Mouse lung, Mouse brain, Mouse spleen
Immunogen:A synthesized peptide derived from human SMC1
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8243
Uniprot:Q14683
Calculated MW:143kDa
Observed MW:160KDa
UniProt Protein Function:Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
NCBI Summary:Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
UniProt Code:Q14683
NCBI GenInfo Identifier:29336622
NCBI Gene ID:8243
NCBI Accession:Q14683.2
UniProt Secondary Accession:Q14683,O14995, Q16351, Q2M228,
UniProt Related Accession:Q14683
Molecular Weight:155 kDa
NCBI Full Name:Structural maintenance of chromosomes protein 1A
NCBI Synonym Full Names:structural maintenance of chromosomes 1A
NCBI Official Symbol:SMC1A  
NCBI Official Synonym Symbols:SMC1; SMCB; CDLS2; SB1.8; SMC1L1; DXS423E; SMC1alpha  
NCBI Protein Information:structural maintenance of chromosomes protein 1A
UniProt Protein Name:Structural maintenance of chromosomes protein 1A
UniProt Synonym Protein Names:Sb1.8
Protein Family:Structural maintenance of chromosomes protein
UniProt Gene Name:SMC1A  

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