SOD1 (EDI) Antibody is a rabbit polyclonal antibody directed against SOD1 (EDI), offered by Assay Genie for research applications. Reported applications include WB, IHC and ELISA. Reported reactivity: Human, Mouse, Rat and Pig. Purified by Protein A.
Superoxide dismutase 1 (SOD1) is a cytosolic antioxidant enzyme that catalyzes the dismutation of superoxide radicals (O₂⁻) into hydrogen peroxide (H₂O₂) and molecular oxygen (O₂), playing a vital role in cellular redox homeostasis. Structurally, SOD1 is a 32 kDa homodimer, with each 16 kDa subunit stabilized by copper and zinc ions, an intra-subunit disulfide bridge, and a tightly packed β-barrel fold. In neurodegenerative disease research—particularly amyotrophic lateral sclerosis (ALS)—SOD1 misfolding and aggregation are key pathological features. One critical conformational change involves the exposure of the dimer interface (EDI), a normally buried region essential for SOD1 stability and enzymatic function. This structural disruption is associated with toxic gain-of-function mechanisms and neuronal degeneration. Conformation-specific antibodies such as SOD1 (EDI) are designed to selectively recognize this exposed dimer interface, enabling researchers to detect early misfolding events in ALS-affected tissues. When used in combination with antibodies like SOD1 (UβB), which targets the unfolded β-barrel region, these tools provide a powerful means of mapping SOD1 conformational states and tracking disease progression. Targeting the exposed dimer interface of SOD1 offers a promising strategy for understanding ALS pathogenesis and developing precision diagnostics and therapeutics in neurodegenerative disease research. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
SOD1 (EDI) Antibody
Product SKU:
STPA00042
Size:
100 µg
Target:
SOD1 (EDI)
Host Species:
Rabbit
Antibody Type:
Polyclonal
Research Areas:
Cancer, Oxidative Stress, Neuroscience, Neurodegeneration, ALS Disease
Buffer:
PBS, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, IHC, ELISA
Purification:
Protein A Purified
Concentration:
1 mg/ml
Reactivity:
Human, Mouse, Rat, Pig
Recommended Dilution:
WB (1:1000); optimal dilutions for assays should be determined by the user.
Specificity:
Recognizes a conformation specific epitope where the dimer interface is exposed.
Guarantee:
12 months from date of dispatch
Immunogen:
C-terminal region of human SOD1, exposed dimer interface (EDI)
