SOD3 (EC) Antibody [4GG11G6] is a mouse monoclonal antibody directed against SOD3 (EC), offered by Assay Genie for research applications. Reported applications include WB, IHC, ICC/IF and ELISA. Reported reactivity: Human, Mouse, Rat and Guinea Pig (Cavia porcellus). Supplied as IgG1 Kappa, purified by Protein G.
Superoxide dismutases (SODs) are essential antioxidant enzymes that protect cells from oxidative stress by catalyzing the dismutation of superoxide radicals (O₂⁻) into molecular oxygen (O₂) and hydrogen peroxide (H₂O₂), which are further detoxified by catalase and glutathione peroxidase. Among the three mammalian isoforms—SOD1 (cytoplasmic), SOD2 (mitochondrial), and SOD3 (extracellular)—SOD3 (extracellular superoxide dismutase, EC-SOD) plays a unique and increasingly recognized role in the central nervous system (CNS). SOD3 is a copper- and zinc-containing homotetramer (~30 kDa) localized exclusively in the extracellular matrix, where it binds to heparan sulfate proteoglycans. This localization enables SOD3 to modulate redox signaling and protect neurons and glial cells from extracellular oxidative insults—key contributors to neuroinflammation and neurodegeneration. Emerging evidence links dysregulation of SOD3 expression and activity to the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). Its extracellular positioning makes SOD3 a promising biomarker and therapeutic target for modulating oxidative stress in the brain. Understanding the distinct biochemical properties and neuroprotective functions of SOD3 is critical for advancing antioxidant-based strategies in neuroscience and neurodegenerative disease research. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
SOD3 (EC) Antibody [4GG11G6]
Product SKU:
STMA00041
Size:
100 µg
Target:
SOD3 (EC)
Host Species:
Mouse
Antibody Type:
Monoclonal
Clone ID:
4GG11G6
Research Areas:
Cancer, Oxidative Stress, Cancer, Cancer Metabolism, Response to Hypoxia, Cell Signaling, Metabolism, Metabolism processes, Hypoxia, Cell Signaling, Metabolism, Redox Metabolism
Buffer:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, IHC, ICC/IF, ELISA
Antibody Isotype:
IgG1 Kappa
Purification:
Protein G Purified
Concentration:
1 mg/ml
Reactivity:
Human, Mouse, Rat, Guinea Pig (Cavia porcellus)
Recommended Dilution:
WB (1:1000), IHC (1:100), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
