UniProt Protein Function: | SRSF10: Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator. Belongs to the splicing factor SR family. 5 isoforms of the human protein are produced by alternative splicing. Protein type: RNA-binding; RNA splicing Chromosomal Location of Human Ortholog: 1p36.11 Cellular Component: nuclear speck; nucleoplasm; nucleus Molecular Function: protein binding; RNA binding Biological Process: mRNA splice site selection; negative regulation of nuclear mRNA splicing, via spliceosome; nuclear mRNA splicing, via spliceosome; regulation of nuclear mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions |
UniProt Protein Details: | |
NCBI Summary: | This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
UniProt Code: | O75494 |
NCBI GenInfo Identifier: | 47605579 |
NCBI Gene ID: | 10772 |
NCBI Accession: | O75494.1 |
UniProt Secondary Accession: | O75494,O60572, Q5JRH9, Q5JRI0, Q5JRI2, Q5JRI3, Q5JRI4 Q96G09, A6NFM6, A6NI42 |
UniProt Related Accession: | O75494 |
Molecular Weight: | 22,135 Da |
NCBI Full Name: | Serine/arginine-rich splicing factor 10 |
NCBI Synonym Full Names: | serine and arginine rich splicing factor 10 |
NCBI Official Symbol: | SRSF10Â Â |
NCBI Official Synonym Symbols: | NSSR; TASR; SRp38; TASR1; TASR2; FUSIP1; FUSIP2; SFRS13; SRrp40; SFRS13A; PPP1R149Â Â |
NCBI Protein Information: | serine/arginine-rich splicing factor 10 |
UniProt Protein Name: | Serine/arginine-rich splicing factor 10 |
UniProt Synonym Protein Names: | 40 kDa SR-repressor protein; SRrp40; FUS-interacting serine-arginine-rich protein 1; Splicing factor SRp38; Splicing factor, arginine/serine-rich 13A; TLS-associated protein with Ser-Arg repeats; TASR; TLS-associated protein with SR repeats; TLS-associated serine-arginine protein; TLS-associated SR protein |
Protein Family: | Serine/arginine-rich splicing factor |
UniProt Gene Name: | SRSF10Â Â |
UniProt Entry Name: | SRS10_HUMAN |