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Anti-SUPV3L1 Antibody (CAB9951)

SKU:
CAB9951
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
  • Cell Biology Antibodies 12 Anti-SUPV3L1 Antibody CAB9951
  • Cell Biology Antibodies 12 Anti-SUPV3L1 Antibody CAB9951
€139 - €419
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Description

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Antibody Name:Anti-SUPV3L1 Antibody
Antibody SKU:CAB9951
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 577-786 of human SUPV3L1 (NP_003162.2).
Application:WB IHC IF
Recommended Dilution:WB 1:1000 - 1:4000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:K-562, Raji, Jurkat, SW620, Mouse heart, Mouse kidney, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 577-786 of human SUPV3L1 (NP_003162.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:APIN KKQP FVCS SLLQ FARQ YSRN EPLT FAWL RRYI KWPL LPPK NIKD LMDL EAVH DVLD LYLW LSYR FMDM FPDA SLIR DLQK ELDG IIQD GVHN ITKL IKMS ETHK LLNL EGFP SGSQ SRLS GTLK SQAR RTRG TKAL GSKA TEPP SPDA GELS LASR LVQQ GLLT PDML KQLE KEWM TQQT EHNK EKTE SGTH PKGT RRKK KEPD SD
Gene ID:6832
Uniprot:Q8IYB8
Cellular Location:Mitochondrion matrix, Nucleus, mitochondrion nucleoid
Calculated MW:87kDa
Observed MW:88kDa
Synonyms:SUPV3L1, SUV3
Background:
UniProt Protein Function:SUPV3L1: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP- dependent multisubstrate helicase, able to unwind double stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. Belongs to the helicase family.
UniProt Protein Details:

Protein type:Mitochondrial; EC 3.6.4.13; Helicase; DNA-binding; RNA-binding

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: mitochondrial matrix; mitochondrion; nucleus

Molecular Function:ATP-dependent RNA helicase activity; DNA binding; DNA helicase activity; double-stranded RNA binding; helicase activity; protein binding; protein homodimerization activity; RNA binding

Biological Process: DNA duplex unwinding; DNA recombination; negative regulation of apoptosis; positive regulation of cell growth; RNA catabolic process

UniProt Code:Q8IYB8
NCBI GenInfo Identifier:74759699
NCBI Gene ID:6832
NCBI Accession:Q8IYB8.1
UniProt Secondary Accession:Q8IYB8,O43630, A8K301,
UniProt Related Accession:Q8IYB8
Molecular Weight:87,991 Da
NCBI Full Name:ATP-dependent RNA helicase SUPV3L1, mitochondrial
NCBI Synonym Full Names:Suv3 like RNA helicase
NCBI Official Symbol:SUPV3L1  
NCBI Official Synonym Symbols:SUV3  
NCBI Protein Information:ATP-dependent RNA helicase SUPV3L1, mitochondrial
UniProt Protein Name:ATP-dependent RNA helicase SUPV3L1, mitochondrial
UniProt Synonym Protein Names:Suppressor of var1 3-like protein 1; SUV3-like protein 1
Protein Family:ATP-dependent RNA helicase
UniProt Gene Name:SUPV3L1  
UniProt Entry Name:SUV3_HUMAN
Anti-SUPV3L1 Polyclonal Antibody (CAB9951)Western blot analysis of extracts of various cell lines, using SUPV3L1 antibody (CAB9951) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Anti-SUPV3L1 Polyclonal Antibody (CAB9951)Immunofluorescence analysis of NIH-3T3 cells using Anti-SUPV3L1 Polyclonal Antibody (CAB9951) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

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