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Anti-SYCP3 Antibody (CAB9548)

SKU:
CAB9548
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle
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Description

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Antibody Name:Anti-SYCP3 Antibody
Antibody SKU:CAB9548
Antibody Size:100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic Peptide of human SYCP3
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Mouse, Rat
Positive Samples:Mouse ovary, Rat ovary
Immunogen:A synthetic Peptide of human SYCP3
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:50511
Uniprot:Q8IZU3
Cellular Location:Chromosome, Nucleus
Calculated MW:27kDa
Observed MW:28kDa
Synonyms:SYCP3, COR1, RPRGL4, SCP3, SPGF4
Background:This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein.
UniProt Protein Function:SYCP3: Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development. Defects in SYCP3 are the cause of spermatogenic failure type 4 (SPGF4). An infertility disorder characterized by azoospermia, a condition of having no sperm present in the ejaculate. Testicular histology shows arrest of spermatogenesis at the pachytene stage of primary spermatocytes. Belongs to the XLR/SYCP3 family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 12q

Cellular Component: chromosome; nucleus

Molecular Function:DNA binding

Biological Process: male meiosis I; cell division; spermatogenesis, exchange of chromosomal proteins

Disease: Spermatogenic Failure 4

NCBI Summary:This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010]
UniProt Code:Q8IZU3
NCBI GenInfo Identifier:74728444
NCBI Gene ID:50511
NCBI Accession:Q8IZU3.1
UniProt Related Accession:Q8IZU3
Molecular Weight:
NCBI Full Name:Synaptonemal complex protein 3
NCBI Synonym Full Names:synaptonemal complex protein 3
NCBI Official Symbol:SYCP3  
NCBI Official Synonym Symbols:COR1; SCP3; SPGF4; RPRGL4  
NCBI Protein Information:synaptonemal complex protein 3
UniProt Protein Name:Synaptonemal complex protein 3
Protein Family:Synaptonemal complex protein
UniProt Gene Name:SYCP3  
UniProt Entry Name:SYCP3_HUMAN
Anti-SYCP3 Polyclonal Antibody (CAB9548)Western blot analysis of extracts of various cell lines, using SYCP3 antibody (CAB9548) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

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