Anti-TACO1 Antibody (CAB15445)

Antibody Name:	Anti-TACO1 Antibody
Antibody SKU:	CAB15445
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-297 of human TACO1 (NP_057444.2).

Application:	WB IHC
Recommended Dilution:	WB 1:200 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	U-251MG, LO2, A375, Mouse brain, Mouse heart, Mouse kidney, Mouse liver, Rat lung

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-297 of human TACO1 (NP_057444.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MSAW AAAS LSRA AARC LLAR GPGV RAAP PRDP RPSH PEPR GCGA APGR TLHF TAAV PAGH NKWS KVRH IKGP KDVE RSRI FSKL CLNI RLAV KEGG PNPE HNSN LANI LEVC RSKH MPKS TIET ALKM EKSK DTYL LYEG RGPG GSSL LIEA LSNS SHKC QADI RHIL NKNG GVMA VGAR HSFD KKGV IVVE VEDR EKKA VNLE RALE MAIE AGAE DVKE TEDE EERN VFKF ICDA SSLH QVRK KLDS LGLC SVSC ALEF IPNS KVQL AEPD LEQA AHLI QALS NHED VIHV YDNI E
Gene ID:	51204
Uniprot:	Q9BSH4
Cellular Location:	Mitochondrion
Calculated MW:	32kDa
Observed MW:	32kDa

Synonyms:	TACO1, CCDC44
Background:	This gene encodes a mitochondrial protein that function as a translational activator of mitochondrially-encoded cytochrome c oxidase 1. Mutations in this gene are associated with Leigh syndrome.

UniProt Protein Function:	CCDC44: Acts as a translational activator of mitochondrially- encoded cytochrome c oxidase 1. Defects in TACO1 are a cause of Leigh syndrome (LS). LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions that is commonly associated with systemic cytochrome c oxidase (COX) deficiency. Belongs to the TACO1 family.
UniProt Protein Details:	Chromosomal Location of Human Ortholog: 17q23.3 Cellular Component: mitochondrion; nucleus Disease: Mitochondrial Complex Iv Deficiency
NCBI Summary:	This gene encodes a mitochondrial protein that function as a translational activator of mitochondrially-encoded cytochrome c oxidase 1. Mutations in this gene are associated with Leigh syndrome.[provided by RefSeq, Mar 2010]
UniProt Code:	Q9BSH4
NCBI GenInfo Identifier:	33516968
NCBI Gene ID:	51204
NCBI Accession:	Q9BSH4.1
UniProt Secondary Accession:	Q9BSH4,Q8N3N6, Q9UI60, B2RD21,
UniProt Related Accession:	Q9BSH4
Molecular Weight:	32,477 Da
NCBI Full Name:	Translational activator of cytochrome c oxidase 1
NCBI Synonym Full Names:	translational activator of cytochrome c oxidase I
NCBI Official Symbol:	TACO1
NCBI Official Synonym Symbols:	CCDC44
NCBI Protein Information:	translational activator of cytochrome c oxidase 1
UniProt Protein Name:	Translational activator of cytochrome c oxidase 1
UniProt Synonym Protein Names:	Coiled-coil domain-containing protein 44; Translational activator of mitochondrially-encoded cytochrome c oxidase I
Protein Family:	Translational activator of cytochrome c oxidase
UniProt Gene Name:	TACO1
UniProt Entry Name:	TACO1_HUMAN

	Western blot analysis of extracts of various cell lines, using TACO1 antibody (CAB15445) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
	Immunohistochemistry of paraffin-embedded Human colon carcinoma using TACO1 Rabbit pAb (CAB15445) at dilution of 1:100 (40x lens).

Antibodies

TACO1 Antibody (PACO08229)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)