UniProt Protein Function: | TAGAP: an apparent GTPase-activating protein (GAP) for Rho monomeric G proteins. May play important roles during T-cell activation. Mutations have been associated with various autoimmune conditions including rheumatoid arthritis, Crohn¿s disease, and celiac disease. Four isoforms of the human protein are produced by alternative splicing.Protein type: GAPs, Rac/Rho; GAPsChromosomal Location of Human Ortholog: 6q25.3Cellular Component: cytosolMolecular Function: GTPase activator activityBiological Process: regulation of small GTPase mediated signal transduction |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013] |
UniProt Code: | Q8N103 |
NCBI GenInfo Identifier: | 74750874 |
NCBI Gene ID: | 117289 |
NCBI Accession: | Q8N103.1 |
UniProt Secondary Accession: | Q8N103,Q2NKM8, Q8NI40, Q96KZ2, Q96QA2 |
UniProt Related Accession: | Q8N103 |
Molecular Weight: | 29,977 Da |
NCBI Full Name: | T-cell activation Rho GTPase-activating protein |
NCBI Synonym Full Names: | T-cell activation RhoGTPase activating protein |
NCBI Official Symbol: | TAGAPÂ Â |
NCBI Official Synonym Symbols: | FKSG15; IDDM21; TAGAP1; ARHGAP47Â Â |
NCBI Protein Information: | T-cell activation Rho GTPase-activating protein |
UniProt Protein Name: | T-cell activation Rho GTPase-activating protein |
UniProt Synonym Protein Names: | T-cell activation GTPase-activating protein |
Protein Family: | T-cell activation Rho GTPase-activating protein |
UniProt Gene Name: | TAGAPÂ Â |
UniProt Entry Name: | TAGAP_HUMAN |